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hdashnow committed Nov 7, 2024
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We are a computational genomics lab at the University of Colorado, [Department of Biomedical Informatics](https://medschool.cuanschutz.edu/dbmi/).
# Current job postings, closing soon!
- [Genomics Software Developer (Data Scientist)](https://cu.taleo.net/careersection/2/jobdetail.ftl?job=35396&lang=en)
- [Genomics Data Analyst (Information Sciences Professional)](https://cu.taleo.net/careersection/2/jobdetail.ftl?job=35393&lang=en)

We are **currently recruiting** postdocs, staff scientists and students. If you're passionate about rare disease genomics and computational method development, please get in touch!


# Welcome to the Dashnow Lab

We are a computational genomics lab at the University of Colorado, [Department of Biomedical Informatics](https://medschool.cuanschutz.edu/dbmi/).

We develop and apply computational methods for the diagnosis and discovery of the genetic basis of rare diseases. The lab has a special emphasis on Short Tandem Repeats and other hard-to-genotype variants.

Typically ~50% of individuals with rare diseases do not receive a genetic diagnosis. For many of these individuals, the causal variant lies in difficult-to-genotype repetitive regions, often variants or genes that have not yet been associated with a disease. Often the evidence for the variant is present in the sequencing data but is either not genotyped, filtered out as an error, or dismissed because it is difficult to interpret. We develop bioinformatic methods to close this gap in genomic analysis. Our research has the potential to transform lives by giving individuals and their families answers and hope for treatment after a long diagnostic odyssey.
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