diff --git a/lms/services/canvas_studio.py b/lms/services/canvas_studio.py
index 87cd0434f3..439e3e9a3d 100644
--- a/lms/services/canvas_studio.py
+++ b/lms/services/canvas_studio.py
@@ -280,19 +280,29 @@ def get_canonical_video_url(self, media_id: str) -> str:
         # Example: "https://hypothesis.instructuremedia.com/api/public/v1/media/4"
         return self._api_url(f"v1/media/{media_id}")
 
-    def get_video_download_url(self, media_id: str) -> str:
+    def get_video_download_url(self, media_id: str) -> str | None:
         """
         Return temporary download URL for a video.
 
+        This may return `None` if the video is not available for download.
+        This can happen for videos imported into Canvas Studio from YouTube
+        or Vimeo.
+
         Security: This method does not check whether the current user should
         have access to this video. See `_admin_api_request`.
         """
 
-        download_rsp = self._bare_api_request(
-            f"v1/media/{media_id}/download", as_admin=True, allow_redirects=False
-        )
-        download_redirect = download_rsp.headers.get("Location")
+        try:
+            download_rsp = self._bare_api_request(
+                f"v1/media/{media_id}/download", as_admin=True, allow_redirects=False
+            )
+        except ExternalRequestError as err:
+            # Canvas Studio returns 422 if the video is not available for download.
+            if err.status_code == 422:
+                return None
+            raise
 
+        download_redirect = download_rsp.headers.get("Location")
         if download_rsp.status_code != 302 or not download_redirect:
             raise ExternalRequestError(
                 message="Media download did not return valid redirect",
diff --git a/lms/static/scripts/frontend_apps/components/LaunchErrorDialog.tsx b/lms/static/scripts/frontend_apps/components/LaunchErrorDialog.tsx
index ce21c56858..385dc57754 100644
--- a/lms/static/scripts/frontend_apps/components/LaunchErrorDialog.tsx
+++ b/lms/static/scripts/frontend_apps/components/LaunchErrorDialog.tsx
@@ -320,6 +320,42 @@ export default function LaunchErrorDialog({
         </ErrorModal>
       );
 
+    case 'canvas_studio_download_unavailable':
+      return (
+        <ErrorModal
+          {...defaultProps}
+          onRetry={undefined}
+          title="Unable to fetch Canvas Studio video"
+        >
+          <p>
+            Only videos uploaded directly to Canvas Studio can be used. Videos
+            hosted on YouTube or Vimeo cannot be used.
+          </p>
+        </ErrorModal>
+      );
+
+    case 'canvas_studio_media_not_found':
+      return (
+        <ErrorModal
+          {...defaultProps}
+          onRetry={undefined}
+          title="Canvas Studio media not found"
+        />
+      );
+
+    case 'canvas_studio_transcript_unavailable':
+      return (
+        <ErrorModal
+          {...defaultProps}
+          onRetry={undefined}
+          title="Video does not have a published transcript"
+        >
+          <p>
+            To use a video with Hypothesis, you must upload or generate captions
+            in Canvas Studio <i>and</i> publish them.
+          </p>
+        </ErrorModal>
+      );
     case 'blackboard_group_set_not_found':
       return (
         <ErrorModal
diff --git a/lms/static/scripts/frontend_apps/components/test/LaunchErrorDialog-test.js b/lms/static/scripts/frontend_apps/components/test/LaunchErrorDialog-test.js
index 16709faf97..bde915ac2c 100644
--- a/lms/static/scripts/frontend_apps/components/test/LaunchErrorDialog-test.js
+++ b/lms/static/scripts/frontend_apps/components/test/LaunchErrorDialog-test.js
@@ -82,6 +82,29 @@ describe('LaunchErrorDialog', () => {
       hasRetry: true,
       withError: true,
     },
+    {
+      errorState: 'canvas_studio_download_unavailable',
+      expectedText:
+        'Only videos uploaded directly to Canvas Studio can be used. Videos hosted on YouTube or Vimeo cannot be used.',
+      expectedTitle: 'Unable to fetch Canvas Studio video',
+      hasRetry: false,
+      withError: true,
+    },
+    {
+      errorState: 'canvas_studio_media_not_found',
+      expectedText: '',
+      expectedTitle: 'Canvas Studio media not found',
+      hasRetry: false,
+      withError: true,
+    },
+    {
+      errorState: 'canvas_studio_transcript_unavailable',
+      expectedText:
+        'To use a video with Hypothesis, you must upload or generate captions in Canvas Studio and publish them.',
+      expectedTitle: 'Video does not have a published transcript',
+      hasRetry: false,
+      withError: true,
+    },
     {
       errorState: 'd2l_file_not_found_in_course_instructor',
       expectedText:
diff --git a/lms/static/scripts/frontend_apps/errors.ts b/lms/static/scripts/frontend_apps/errors.ts
index c94442f82c..fdcf625364 100644
--- a/lms/static/scripts/frontend_apps/errors.ts
+++ b/lms/static/scripts/frontend_apps/errors.ts
@@ -18,6 +18,9 @@ export type LTILaunchServerErrorCode =
   | 'canvas_group_set_not_found'
   | 'canvas_page_not_found_in_course'
   | 'canvas_student_not_in_group'
+  | 'canvas_studio_download_unavailable'
+  | 'canvas_studio_transcript_unavailable'
+  | 'canvas_studio_media_not_found'
   | 'd2l_file_not_found_in_course_instructor'
   | 'd2l_file_not_found_in_course_student'
   | 'd2l_group_set_empty'
@@ -162,6 +165,9 @@ export function isLTILaunchServerError(error: ErrorLike): error is APIError {
       'canvas_group_set_not_found',
       'canvas_group_set_empty',
       'canvas_student_not_in_group',
+      'canvas_studio_download_unavailable',
+      'canvas_studio_transcript_unavailable',
+      'canvas_studio_media_not_found',
       'vitalsource_user_not_found',
       'vitalsource_no_book_license',
       'moodle_page_not_found_in_course',
diff --git a/lms/views/api/canvas_studio.py b/lms/views/api/canvas_studio.py
index fed348bb7c..91c6d055fd 100644
--- a/lms/views/api/canvas_studio.py
+++ b/lms/views/api/canvas_studio.py
@@ -4,16 +4,29 @@
 See `CanvasStudioService` for more details.
 """
 
-from pyramid.httpexceptions import HTTPBadRequest, HTTPFound
+from pyramid.httpexceptions import HTTPFound
 from pyramid.view import view_config
 
 from lms.security import Permissions
 from lms.services import CanvasStudioService
 from lms.services.canvas_studio import replace_localhost_in_url
+from lms.services.exceptions import SerializableError
 from lms.validation.authentication import OAuthCallbackSchema
 from lms.views.helpers import via_video_url
 
 
+class CanvasStudioLaunchError(SerializableError):
+    """
+    An error occurred while launching a Canvas Studio assignment.
+
+    This exception is used for non-authorization errors that prevent a
+    Canvas Studio assignment from being launched.
+    """
+
+    def __init__(self, error_code: str, message: str):
+        super().__init__(error_code=error_code, message=message)
+
+
 # View for authorization popup which redirects to Canvas Studio's OAuth
 # authorization endpoint.
 #
@@ -135,15 +148,31 @@ def via_url(request):
     document_url = assignment.document_url
     media_id = CanvasStudioService.media_id_from_url(document_url)
     if not media_id:
-        raise HTTPBadRequest("Unable to get Canvas Studio media ID")
+        raise CanvasStudioLaunchError(
+            "canvas_studio_media_not_found", "Unable to get Canvas Studio media ID"
+        )
 
     svc = request.find_service(CanvasStudioService)
     canonical_url = svc.get_canonical_video_url(media_id)
+
+    # Get the video download URL, then the transcript. We do things in this
+    # order because if the video cannot be used (eg. because it is a Vimeo
+    # upload), there is no point in the user uploading a transcript, if that is
+    # also missing.
+
     download_url = svc.get_video_download_url(media_id)
-    transcript_url = svc.get_transcript_url(media_id)
+    if not download_url:
+        raise CanvasStudioLaunchError(
+            "canvas_studio_download_unavailable",
+            "Hypothesis was unable to fetch the video",
+        )
 
+    transcript_url = svc.get_transcript_url(media_id)
     if not transcript_url:
-        raise HTTPBadRequest("This video does not have a published transcript")
+        raise CanvasStudioLaunchError(
+            "canvas_studio_transcript_unavailable",
+            "This video does not have a published transcript",
+        )
 
     return {
         "via_url": via_video_url(request, canonical_url, download_url, transcript_url)
diff --git a/tests/unit/lms/services/canvas_studio_test.py b/tests/unit/lms/services/canvas_studio_test.py
index 7223abe10c..4a10b4182d 100644
--- a/tests/unit/lms/services/canvas_studio_test.py
+++ b/tests/unit/lms/services/canvas_studio_test.py
@@ -191,6 +191,9 @@ def test_get_video_download_error(self, svc):
             svc.get_video_download_url("456")
         assert Any.instance_of(exc_info.value.response).with_attrs({"status_code": 404})
 
+    def test_get_video_download_url_returns_None_if_video_not_available(self, svc):
+        assert svc.get_video_download_url("800") is None
+
     def test_get_video_download_url_fails_if_admin_email_not_set(
         self, svc, pyramid_request
     ):
@@ -412,6 +415,11 @@ def handler(url, allow_redirects=True):
                 case "media/456/download":
                     status_code = 404
                     json_data = {}
+                case "media/800/download":
+                    # Simulate response in case where video is hosted on
+                    # YouTube or Vimeo, so not available for download.
+                    status_code = 422
+                    json_data = {}
 
                 case _:  # pragma: nocover
                     raise ValueError(f"Unexpected URL {url}")
diff --git a/tests/unit/lms/views/api/canvas_studio_test.py b/tests/unit/lms/views/api/canvas_studio_test.py
index 4b561b4be8..30998321e7 100644
--- a/tests/unit/lms/views/api/canvas_studio_test.py
+++ b/tests/unit/lms/views/api/canvas_studio_test.py
@@ -2,7 +2,7 @@
 
 import pytest
 from h_matchers import Any
-from pyramid.httpexceptions import HTTPBadRequest, HTTPFound
+from pyramid.httpexceptions import HTTPFound
 
 import lms.views.api.canvas_studio as views
 
@@ -104,7 +104,8 @@ def test_it_raises_if_transcript_not_available(
         canvas_studio_service.get_transcript_url.return_value = None
 
         with pytest.raises(
-            HTTPBadRequest, match="This video does not have a published transcript"
+            views.CanvasStudioLaunchError,
+            match="This video does not have a published transcript",
         ):
             views.via_url(pyramid_request)
 
@@ -115,7 +116,18 @@ def test_it_raises_if_document_url_not_valid(
             "https://not-a-canvas-studio-url.com"
         )
         with pytest.raises(
-            HTTPBadRequest, match="Unable to get Canvas Studio media ID"
+            views.CanvasStudioLaunchError, match="Unable to get Canvas Studio media ID"
+        ):
+            views.via_url(pyramid_request)
+
+    def test_it_raises_if_download_not_available(
+        self, canvas_studio_service, pyramid_request
+    ):
+        canvas_studio_service.get_video_download_url.return_value = None
+
+        with pytest.raises(
+            views.CanvasStudioLaunchError,
+            match="Hypothesis was unable to fetch the video",
         ):
             views.via_url(pyramid_request)