diff --git a/src/globus_sdk/client.py b/src/globus_sdk/client.py
index a362cd7ea..38bdab069 100644
--- a/src/globus_sdk/client.py
+++ b/src/globus_sdk/client.py
@@ -304,8 +304,8 @@ def request(
             method=method,
             url=url,
             data=utils.PayloadWrapper._prepare(data),
-            query_params=query_params,
-            headers=rheaders,
+            query_params=utils.filter_missing(query_params),
+            headers=utils.filter_missing(rheaders),
             encoding=encoding,
             authorizer=self.authorizer,
             allow_redirects=allow_redirects,
diff --git a/src/globus_sdk/utils.py b/src/globus_sdk/utils.py
index 7ca96c458..1891558f4 100644
--- a/src/globus_sdk/utils.py
+++ b/src/globus_sdk/utils.py
@@ -57,6 +57,12 @@ def __repr__(self) -> str:
 MISSING = MissingType()
 
 
+def filter_missing(data: dict[str, t.Any] | None) -> dict[str, t.Any] | None:
+    if data is None:
+        return None
+    return {k: v for k, v in data.items() if v is not MISSING}
+
+
 def sha256_string(s: str) -> str:
     return hashlib.sha256(s.encode("utf-8")).hexdigest()
 
diff --git a/tests/functional/base_client/test_filter_missing.py b/tests/functional/base_client/test_filter_missing.py
new file mode 100644
index 000000000..a90b828d6
--- /dev/null
+++ b/tests/functional/base_client/test_filter_missing.py
@@ -0,0 +1,57 @@
+import json
+import urllib.parse
+
+import pytest
+
+from globus_sdk import utils
+from globus_sdk._testing import RegisteredResponse, get_last_request, load_response
+
+
+@pytest.fixture(autouse=True)
+def setup_mock_responses():
+    load_response(
+        RegisteredResponse(
+            path="https://foo.api.globus.org/bar",
+            json={"foo": "bar"},
+        )
+    )
+    load_response(
+        RegisteredResponse(
+            path="https://foo.api.globus.org/bar",
+            method="POST",
+            json={"foo": "bar"},
+        )
+    )
+
+
+def test_query_params_can_filter_missing(client):
+    res = client.get("/bar", query_params={"foo": "bar", "baz": utils.MISSING})
+    assert res.http_status == 200
+    req = get_last_request()
+    assert req.params == {"foo": "bar"}
+
+
+def test_headers_can_filter_missing(client):
+    res = client.get("/bar", headers={"foo": "bar", "baz": utils.MISSING})
+    assert res.http_status == 200
+    req = get_last_request()
+    assert req.headers["foo"] == "bar"
+    assert "baz" not in req.headers
+
+
+def test_json_body_can_filter_missing(client):
+    res = client.post("/bar", data={"foo": "bar", "baz": utils.MISSING})
+    assert res.http_status == 200
+    req = get_last_request()
+    sent = json.loads(req.body)
+    assert sent == {"foo": "bar"}
+
+
+def test_form_body_can_filter_missing(client):
+    res = client.post(
+        "/bar", data={"foo": "bar", "baz": utils.MISSING}, encoding="form"
+    )
+    assert res.http_status == 200
+    req = get_last_request()
+    sent = urllib.parse.parse_qs(req.body)
+    assert sent == {"foo": ["bar"]}