biolink-model.json

{
   "$id": "https://w3id.org/biolink/biolink-model",
   "$schema": "http://json-schema.org/draft-04/schema#",
   "definitions": {
      "actively_involved_in": {
         "description": "holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects": {
         "description": "describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_abundance_of": {
         "description": "holds between two molecular entities where the action or effect of one changes the amount of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_activity_of": {
         "description": "holds between two molecular entities where the action or effect of one changes the activity of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_degradation_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the rate of degradation of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_expression_of": {
         "description": "holds between two molecular entities where the action or effect of one changes the level of expression of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_folding_of": {
         "description": "holds between two molecular entities where the action or effect of one changes the rate or quality of folding of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_localization_of": {
         "description": "holds between two molecular entities where the action or effect of one changes the localization of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_metabolic_processing_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the metabolic processing of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_molecular_modification_of": {
         "description": "holds between two molecular entities where the action or effect of one leads changes in the molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_mutation_rate_of": {
         "description": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity impacts the rate of mutation of the genomic entity within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_response_to": {
         "description": "holds between two molecular entities where the action or effect of one impacts the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_risk_for": {
         "description": "holds between two entities where exposure to one entity alters the chance of developing the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_secretion_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the rate of secretion of the other out of a cell, gland, or organ",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_splicing_of": {
         "description": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity impacts the splicing of the mRNA",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_stability_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the stability of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_synthesis_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the rate of chemical synthesis of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_transport_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the rate of transport of the other across some boundary in a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "affects_uptake_of": {
         "description": "holds between two molecular entities where the action or effect of one impacts the rate of uptake of the other into of a cell, gland, or organ",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "aggregate_statistic": {
         "type": "string"
      },
      "association_slot": {
         "description": "any slot that relates an association to another entity",
         "type": "string"
      },
      "association_type": {
         "description": "connects an association to the type of association (e.g. gene to phenotype)",
         "type": "string"
      },
      "biomarker_for": {
         "description": "holds between a measurable molecular entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "capable_of": {
         "description": "holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "category": {
         "description": "Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class. In a neo4j database this MAY correspond to the neo4j label tag",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "causes": {
         "description": "holds between two entities where the occurrence, existence, or activity of one causes the occurrence or  generation of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "change_is_catalyzed_by": {
         "description": "hyperedge connecting an association between two causally connected entities (for example, two chemical entities, or a chemical entity in that changes location) and the gene product, gene, or complex that enables or catalyzes the change.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "clinical_modifier_qualifier": {
         "description": "Used to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects",
         "type": "string"
      },
      "coexists_with": {
         "description": "holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "colocalizes_with": {
         "description": "holds between two entities that are observed to be located in the same place.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "contributes_to": {
         "description": "holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "correlated_with": {
         "description": "holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "creation_date": {
         "description": "date on which thing was created. This can be applied to nodes or edges",
         "type": "string"
      },
      "decreases_abundance_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the amount of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_activity_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the activity of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_degradation_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate of degradation of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_expression_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the level of expression of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_folding_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate or quality of folding of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_localization_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the proper localization of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_metabolic_processing_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate of metabolic processing of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_molecular_modification_of": {
         "description": "holds between two molecular entities where the action or effect of one leads to decreased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_mutation_rate_of": {
         "description": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity decreases the rate of mutation of the genomic entity within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_response_to": {
         "description": "holds between two molecular entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_secretion_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate of secretion of the other out of a cell, gland, or organ",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_splicing_of": {
         "description": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity decreases the proper splicing of the mRNA",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_stability_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the stability of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_synthesis_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate of chemical synthesis of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_transport_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate of transport of the other across some boundary in a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "decreases_uptake_of": {
         "description": "holds between two molecular entities where the action or effect of one decreases the rate of uptake of the other into of a cell, gland, or organ",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "derives_from": {
         "description": "holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "derives_into": {
         "description": "holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "description": {
         "description": "a human-readable description of a thing",
         "type": "string"
      },
      "disrupts": {
         "description": "describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "distribution": {
         "type": "string"
      },
      "downloadURL": {
         "type": "string"
      },
      "drug": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "edge_label": {
         "description": "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes.",
         "type": "string"
      },
      "enabled_by": {
         "description": "holds between a process and a physical entity, where the physical entity executes the process",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "end_interbase_coordinate": {
         "type": "string"
      },
      "expressed_in": {
         "description": "holds between a gene or gene product and an anatomical entity in which it is expressed",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "expresses": {
         "description": "holds between an anatomical entity and gene or gene product that is expressed there",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "filler": {
         "description": "The value in a property-value tuple",
         "type": "string"
      },
      "frequency_qualifier": {
         "description": "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject",
         "type": "string"
      },
      "full_name": {
         "description": "a long-form human readable name for a thing",
         "type": "string"
      },
      "gene_associated_with_condition": {
         "description": "holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "genetically_interacts_with": {
         "description": "holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "genome_build": {
         "description": "TODO",
         "type": "string"
      },
      "has_attribute": {
         "description": "connects any named thing to an attribute",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_attribute_type": {
         "description": "connects an attribute to a class that describes it",
         "type": "string"
      },
      "has_biological_sequence": {
         "description": "connects a genomic feature to its sequence",
         "type": "string"
      },
      "has_biomarker": {
         "description": "holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_chemical_formula": {
         "description": "description of chemical compound based on element symbols",
         "type": "string"
      },
      "has_confidence_level": {
         "description": "connects an association to a qualitative term denoting the level of confidence",
         "type": "string"
      },
      "has_count": {
         "description": "number of things with a particular property",
         "type": "string"
      },
      "has_evidence": {
         "description": "connects an association to an instance of supporting evidence",
         "type": "string"
      },
      "has_exposure_parts": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_gene": {
         "description": "connects and entity to a single gene",
         "type": "string"
      },
      "has_gene_product": {
         "description": "holds between a gene and a transcribed and/or translated product generated from it",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_input": {
         "description": "holds between a process and a continuant, where the continuant is an input into the process",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_molecular_consequence": {
         "description": "connects a sequence variant to a class describing the molecular consequence. E.g.  SO:0001583",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_numeric_value": {
         "description": "connects a quantity value to a number",
         "type": "string"
      },
      "has_output": {
         "description": "holds between a process and a continuant, where the continuant is an output of the process",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_part": {
         "description": "holds between wholes and their parts (material entities or processes)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_participant": {
         "description": "holds between a process and a continuant, where the continuant is somehow involved in the process",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_percentage": {
         "description": "equivalent to has quotient multiplied by 100",
         "type": "string"
      },
      "has_phenotype": {
         "description": "holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature).",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_qualitative_value": {
         "description": "connects an attribute to a value",
         "type": "string"
      },
      "has_quantitative_value": {
         "description": "connects an attribute to a value",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "has_quotient": {
         "type": "string"
      },
      "has_total": {
         "description": "total number of things in a particular reference set",
         "type": "string"
      },
      "has_unit": {
         "description": "connects a quantity value to a unit",
         "type": "string"
      },
      "has_zygosity": {
         "type": "string"
      },
      "homologous_to": {
         "description": "holds between two biological entities that have common evolutionary origin",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "id": {
         "description": "A unique identifier for a thing. Must be either a CURIE shorthand for a URI or a complete URI",
         "type": "string"
      },
      "in_cell_population_with": {
         "description": "holds between two genes or gene products that are expressed in the same cell type or population",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "in_complex_with": {
         "description": "holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "in_pathway_with": {
         "description": "holds between two genes or gene products that are part of in the same biological pathway",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "in_taxon": {
         "description": "connects a thing to a class representing a taxon",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_abundance_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the amount of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_activity_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the activity of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_degradation_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate of degradation of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_expression_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the level of expression of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_folding_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate or quality of folding of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_localization_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the proper localization of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_metabolic_processing_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate of metabolic processing of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_molecular_modification_of": {
         "description": "holds between two molecular entities where the action or effect of one leads to increased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_mutation_rate_of": {
         "description": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity increases the rate of mutation of the genomic entity within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_response_to": {
         "description": "holds between two molecular entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_secretion_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate of secretion of the other out of a cell, gland, or organ",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_splicing_of": {
         "description": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity increases the proper splicing of the mRNA",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_stability_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the stability of the other within a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_synthesis_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate of chemical synthesis of the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_transport_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate of transport of the other across some boundary in a system of interest",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "increases_uptake_of": {
         "description": "holds between two molecular entities where the action or effect of one increases the rate of uptake of the other into of a cell, gland, or organ",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "interacting_molecules_category": {
         "type": "string"
      },
      "interacts_with": {
         "description": "holds between any two entities that directly or indirectly interact with each other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "interbase_coordinate": {
         "description": "TODO",
         "type": "string"
      },
      "iri": {
         "description": "An IRI for the node. This is determined by the id using expansion rules.",
         "type": "string"
      },
      "latitude": {
         "description": "latitude",
         "type": "string"
      },
      "located_in": {
         "description": "holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "location_of": {
         "description": "holds between material entity or site and a material entity that is located within it (but not considered a part of it)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "longitude": {
         "description": "longitude",
         "type": "string"
      },
      "manifestation_of": {
         "description": "used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "model_of": {
         "description": "holds between an entity and some other entity it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "molecularly_interacts_with": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "name": {
         "description": "A human-readable name for a thing",
         "type": "string"
      },
      "negated": {
         "description": "if set to true, then the association is negated i.e. is not true",
         "type": "string"
      },
      "negatively_regulates": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "negatively_regulates_entity_to_entity": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "negatively_regulates_process_to_process": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "node_property": {
         "description": "A grouping for any property that holds between a node and a value",
         "type": "string"
      },
      "object": {
         "description": "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object.",
         "type": "string"
      },
      "occurs_in": {
         "description": "holds between a process and a material entity or site within which the process occurs",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "onset_qualifier": {
         "description": "a qualifier used in a phenotypic association to state when the phenotype appears is in the subject",
         "type": "string"
      },
      "orthologous_to": {
         "description": "a homology relationship between entities (typically genes) that diverged after a speciation event.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "overlaps": {
         "description": "holds between entties that overlap in their extents (materials or processes)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "paralogous_to": {
         "description": "a homology relationship that holds between entities (typically genes) that diverged after a duplication event.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "part_of": {
         "description": "holds between parts and wholes (material entities or processes)",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "participates_in": {
         "description": "holds between a continuant and a process, where the continuant is somehow involved in the process",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "phase": {
         "description": "TODO",
         "type": "string"
      },
      "physically_interacts_with": {
         "description": "holds between two entities that make physical contact as part of some interaction",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "positively_regulates": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "positively_regulates_entity_to_entity": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "positively_regulates_process_to_process": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "precedes": {
         "description": "holds between two processes, where one completes before the other begins",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "predisposes": {
         "description": "holds between two entities where exposure to one entity increases the chance of developing the other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "prevents": {
         "description": "holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical substance, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature.",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "produces": {
         "description": "holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "provided_by": {
         "description": "connects an association to the agent (person, organization or group) that provided it",
         "type": "string"
      },
      "publications": {
         "description": "connects an association to publications supporting the association",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "qualifiers": {
         "description": "connects an association to qualifiers that modify or qualify the meaning of that association",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "quantifier_qualifier": {
         "description": "A measurable quantity for the object of the association",
         "type": "string"
      },
      "regulates": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "regulates_entity_to_entity": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "regulates_process_to_process": {
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "related_to": {
         "description": "A relationship that is asserted between two named things",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "relation": {
         "description": "the relationship type by which a subject is connected to an object in an association",
         "type": "string"
      },
      "retrievedOn": {
         "type": "string"
      },
      "same_as": {
         "description": "holds between two entities that are considered equivalent to each other",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "sequence_variant_qualifier": {
         "description": "a qualifier used in an association where the variant",
         "type": "string"
      },
      "severity_qualifier": {
         "description": "a qualifier used in a phenotypic association to state how severe the phenotype is in the subject",
         "type": "string"
      },
      "sex_qualifier": {
         "description": "a qualifier used in a phenotypic association to state whether the association is specific to a particular sex.",
         "type": "string"
      },
      "source_data_file": {
         "type": "string"
      },
      "source_version": {
         "type": "string"
      },
      "source_web_page": {
         "type": "string"
      },
      "stage_qualifier": {
         "description": "stage at which expression takes place",
         "type": "string"
      },
      "start_interbase_coordinate": {
         "type": "string"
      },
      "subclass_of": {
         "description": "holds between two classes where the domain class is a specialization of the range class",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "subject": {
         "description": "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object.",
         "type": "string"
      },
      "synonym": {
         "description": "Alternate human-readable names for a thing",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "systematic_synonym": {
         "description": "more commonly used for gene symbols in yeast",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "timepoint": {
         "description": "a point in time",
         "type": "string"
      },
      "title": {
         "type": "string"
      },
      "treated_by": {
         "description": "holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is used to treat the condition",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "treats": {
         "description": "holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it is used to treat",
         "items": {
            "type": "string"
         },
         "type": "array"
      },
      "type": {
         "type": "string"
      },
      "update_date": {
         "description": "date on which thing was updated. This can be applied to nodes or edges",
         "type": "string"
      },
      "versionOf": {
         "type": "string"
      },
      "xenologous_to": {
         "description": "a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor.",
         "items": {
            "type": "string"
         },
         "type": "array"
      }
   },
   "properties": {
      "AbstractEntity": {
         "description": "Any thing that is not a process or a physical mass-bearing entity",
         "properties": {},
         "title": "AbstractEntity",
         "type": "object"
      },
      "ActivityAndBehavior": {
         "description": "Activity or behavior of any independent integral living, organization or mechanical actor in the world",
         "properties": {},
         "title": "ActivityAndBehavior",
         "type": "object"
      },
      "AnatomicalEntity": {
         "description": "A subcellular location, cell type or gross anatomical part",
         "properties": {
            "expresses": {
               "description": "holds between an anatomical entity and gene or gene product that is expressed there",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "in_taxon": {
               "description": "connects a thing to a class representing a taxon",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "AnatomicalEntity",
         "type": "object"
      },
      "AnatomicalEntityToAnatomicalEntityAssociation": {
         "description": "",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "AnatomicalEntityToAnatomicalEntityAssociation",
         "type": "object"
      },
      "AnatomicalEntityToAnatomicalEntityOntogenicAssociation": {
         "description": "A relationship between two anatomical entities where the relationship is ontogenic, i.e the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "AnatomicalEntityToAnatomicalEntityOntogenicAssociation",
         "type": "object"
      },
      "AnatomicalEntityToAnatomicalEntityPartOfAssociation": {
         "description": "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "AnatomicalEntityToAnatomicalEntityPartOfAssociation",
         "type": "object"
      },
      "Association": {
         "description": "A typed association between two entities, supported by evidence",
         "properties": {
            "association_slot": {
               "description": "any slot that relates an association to another entity",
               "type": "string"
            },
            "association_type": {
               "description": "connects an association to the type of association (e.g. gene to phenotype)",
               "type": "string"
            },
            "change_is_catalyzed_by": {
               "description": "hyperedge connecting an association between two causally connected entities (for example, two chemical entities, or a chemical entity in that changes location) and the gene product, gene, or complex that enables or catalyzes the change.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "clinical_modifier_qualifier": {
               "description": "Used to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects",
               "type": "string"
            },
            "edge_label": {
               "description": "A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes.",
               "required": true,
               "type": "string"
            },
            "frequency_qualifier": {
               "description": "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject",
               "type": "string"
            },
            "has_confidence_level": {
               "description": "connects an association to a qualitative term denoting the level of confidence",
               "type": "string"
            },
            "has_evidence": {
               "description": "connects an association to an instance of supporting evidence",
               "type": "string"
            },
            "id": {
               "description": "A unique identifier for an association",
               "required": true,
               "type": "string"
            },
            "negated": {
               "description": "if set to true, then the association is negated i.e. is not true",
               "type": "string"
            },
            "object": {
               "description": "connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object.",
               "required": true,
               "type": "string"
            },
            "onset_qualifier": {
               "description": "a qualifier used in a phenotypic association to state when the phenotype appears is in the subject",
               "type": "string"
            },
            "provided_by": {
               "description": "connects an association to the agent (person, organization or group) that provided it",
               "type": "string"
            },
            "publications": {
               "description": "connects an association to publications supporting the association",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "qualifiers": {
               "description": "connects an association to qualifiers that modify or qualify the meaning of that association",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "quantifier_qualifier": {
               "description": "A measurable quantity for the object of the association",
               "type": "string"
            },
            "relation": {
               "description": "the relationship type by which a subject is connected to an object in an association",
               "required": true,
               "type": "string"
            },
            "sequence_variant_qualifier": {
               "description": "a qualifier used in an association where the variant",
               "type": "string"
            },
            "severity_qualifier": {
               "description": "a qualifier used in a phenotypic association to state how severe the phenotype is in the subject",
               "type": "string"
            },
            "sex_qualifier": {
               "description": "a qualifier used in a phenotypic association to state whether the association is specific to a particular sex.",
               "type": "string"
            },
            "stage_qualifier": {
               "description": "stage at which expression takes place",
               "type": "string"
            },
            "subject": {
               "description": "connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object.",
               "required": true,
               "type": "string"
            }
         },
         "title": "Association",
         "type": "object"
      },
      "Attribute": {
         "description": "A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material.",
         "properties": {
            "category": {
               "description": "Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class. In a neo4j database this MAY correspond to the neo4j label tag",
               "items": {
                  "type": "string"
               },
               "required": true,
               "type": "array"
            },
            "description": {
               "description": "a human-readable description of a thing",
               "type": "string"
            },
            "full_name": {
               "description": "a long-form human readable name for a thing",
               "type": "string"
            },
            "has_attribute_type": {
               "description": "connects an attribute to a class that describes it",
               "type": "string"
            },
            "has_qualitative_value": {
               "description": "connects an attribute to a value",
               "type": "string"
            },
            "has_quantitative_value": {
               "description": "connects an attribute to a value",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "id": {
               "description": "A unique identifier for a thing. Must be either a CURIE shorthand for a URI or a complete URI",
               "required": true,
               "type": "string"
            },
            "interacts_with": {
               "description": "holds between any two entities that directly or indirectly interact with each other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "iri": {
               "description": "An IRI for the node. This is determined by the id using expansion rules.",
               "type": "string"
            },
            "name": {
               "description": "A human-readable name for a thing",
               "required": true,
               "type": "string"
            },
            "node_property": {
               "description": "A grouping for any property that holds between a node and a value",
               "type": "string"
            },
            "related_to": {
               "description": "A relationship that is asserted between two named things",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "subclass_of": {
               "description": "holds between two classes where the domain class is a specialization of the range class",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "synonym": {
               "description": "Alternate human-readable names for a thing",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "systematic_synonym": {
               "description": "more commonly used for gene symbols in yeast",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "Attribute",
         "type": "object"
      },
      "BiologicalProcess": {
         "description": "One or more causally connected executions of molecular functions",
         "properties": {},
         "title": "BiologicalProcess",
         "type": "object"
      },
      "BiologicalProcessOrActivity": {
         "description": "Either an individual molecular activity, or a collection of causally connected molecular activities",
         "properties": {
            "enabled_by": {
               "description": "holds between a process and a physical entity, where the physical entity executes the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_input": {
               "description": "holds between a process and a continuant, where the continuant is an input into the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_output": {
               "description": "holds between a process and a continuant, where the continuant is an output of the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_participant": {
               "description": "holds between a process and a continuant, where the continuant is somehow involved in the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "precedes": {
               "description": "holds between two processes, where one completes before the other begins",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "regulates_process_to_process": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "BiologicalProcessOrActivity",
         "type": "object"
      },
      "BiologicalSex": {
         "description": "",
         "properties": {},
         "title": "BiologicalSex",
         "type": "object"
      },
      "Carbohydrate": {
         "description": "",
         "properties": {},
         "title": "Carbohydrate",
         "type": "object"
      },
      "Case": {
         "description": "An individual organism that has a patient role in some clinical context.",
         "properties": {},
         "title": "Case",
         "type": "object"
      },
      "CaseToPhenotypicFeatureAssociation": {
         "description": "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype",
         "properties": {},
         "title": "CaseToPhenotypicFeatureAssociation",
         "type": "object"
      },
      "Cell": {
         "description": "",
         "properties": {},
         "title": "Cell",
         "type": "object"
      },
      "CellLine": {
         "description": "",
         "properties": {},
         "title": "CellLine",
         "type": "object"
      },
      "CellLineToDiseaseOrPhenotypicFeatureAssociation": {
         "description": "An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype",
         "properties": {
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "CellLineToDiseaseOrPhenotypicFeatureAssociation",
         "type": "object"
      },
      "CellularComponent": {
         "description": "A location in or around a cell",
         "properties": {},
         "title": "CellularComponent",
         "type": "object"
      },
      "ChemicalSubstance": {
         "description": "May be a chemical entity or a formulation with a chemical entity as active ingredient, or a complex material with multiple chemical entities as part",
         "properties": {},
         "title": "ChemicalSubstance",
         "type": "object"
      },
      "ChemicalToChemicalAssociation": {
         "description": "A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another.",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "ChemicalToChemicalAssociation",
         "type": "object"
      },
      "ChemicalToChemicalDerivationAssociation": {
         "description": "A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:\n  IF\n  R has-input C1 AND\n  R has-output C2 AND\n  R enabled-by P AND\n  R type Reaction\n  THEN\n  C1 derives-into C2 <<change is catalyzed by P>>",
         "properties": {
            "change_is_catalyzed_by": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "ChemicalToChemicalDerivationAssociation",
         "type": "object"
      },
      "ChemicalToDiseaseOrPhenotypicFeatureAssociation": {
         "description": "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "ChemicalToDiseaseOrPhenotypicFeatureAssociation",
         "type": "object"
      },
      "ChemicalToGeneAssociation": {
         "description": "An interaction between a chemical entity and a gene or gene product",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "ChemicalToGeneAssociation",
         "type": "object"
      },
      "ChemicalToPathwayAssociation": {
         "description": "An interaction between a chemical entity and a biological process or pathway",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "ChemicalToPathwayAssociation",
         "type": "object"
      },
      "ClinicalEntity": {
         "description": "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities",
         "properties": {},
         "title": "ClinicalEntity",
         "type": "object"
      },
      "ClinicalIntervention": {
         "description": "",
         "properties": {},
         "title": "ClinicalIntervention",
         "type": "object"
      },
      "ClinicalModifier": {
         "description": "Used to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects",
         "properties": {},
         "title": "ClinicalModifier",
         "type": "object"
      },
      "ClinicalTrial": {
         "description": "",
         "properties": {},
         "title": "ClinicalTrial",
         "type": "object"
      },
      "CodingSequence": {
         "description": "",
         "properties": {},
         "title": "CodingSequence",
         "type": "object"
      },
      "ConfidenceLevel": {
         "description": "Level of confidence in a statement",
         "properties": {},
         "title": "ConfidenceLevel",
         "type": "object"
      },
      "DataFile": {
         "description": "",
         "properties": {},
         "title": "DataFile",
         "type": "object"
      },
      "DataSet": {
         "description": "",
         "properties": {},
         "title": "DataSet",
         "type": "object"
      },
      "DataSetSummary": {
         "description": "",
         "properties": {
            "source_web_page": {
               "type": "string"
            }
         },
         "title": "DataSetSummary",
         "type": "object"
      },
      "DataSetVersion": {
         "description": "",
         "properties": {
            "distribution": {
               "type": "string"
            },
            "source_data_file": {
               "type": "string"
            },
            "title": {
               "type": "string"
            },
            "type": {
               "type": "string"
            },
            "versionOf": {
               "type": "string"
            }
         },
         "title": "DataSetVersion",
         "type": "object"
      },
      "Device": {
         "description": "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment",
         "properties": {},
         "title": "Device",
         "type": "object"
      },
      "Disease": {
         "description": "",
         "properties": {},
         "title": "Disease",
         "type": "object"
      },
      "DiseaseOrPhenotypicFeature": {
         "description": "Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate.",
         "properties": {
            "correlated_with": {
               "description": "holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_biomarker": {
               "description": "holds between a disease or phenotypic feature and a measurable molecular entity that is used as an indicator of the presence or state of the disease or feature.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "in_taxon": {
               "description": "connects a thing to a class representing a taxon",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "treated_by": {
               "description": "holds between a disease or phenotypic feature and a therapeutic process or chemical substance that is used to treat the condition",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "DiseaseOrPhenotypicFeature",
         "type": "object"
      },
      "DiseaseOrPhenotypicFeatureAssociationToLocationAssociation": {
         "description": "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site.",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "DiseaseOrPhenotypicFeatureAssociationToLocationAssociation",
         "type": "object"
      },
      "DiseaseToPhenotypicFeatureAssociation": {
         "description": "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way",
         "properties": {},
         "title": "DiseaseToPhenotypicFeatureAssociation",
         "type": "object"
      },
      "DistributionLevel": {
         "description": "",
         "properties": {
            "downloadURL": {
               "type": "string"
            }
         },
         "title": "DistributionLevel",
         "type": "object"
      },
      "DistributionLevel": {
         "description": "",
         "properties": {
            "downloadURL": {
               "type": "string"
            }
         },
         "title": "DistributionLevel",
         "type": "object"
      },
      "Drug": {
         "description": "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease",
         "properties": {},
         "title": "Drug",
         "type": "object"
      },
      "DrugExposure": {
         "description": "A drug exposure is an intake of a particular chemical substance",
         "properties": {
            "drug": {
               "items": {
                  "type": "string"
               },
               "required": true,
               "type": "array"
            }
         },
         "title": "DrugExposure",
         "type": "object"
      },
      "Environment": {
         "description": "A feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes",
         "properties": {},
         "title": "Environment",
         "type": "object"
      },
      "EnvironmentToPhenotypicFeatureAssociation": {
         "description": "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype",
         "properties": {
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "EnvironmentToPhenotypicFeatureAssociation",
         "type": "object"
      },
      "EnvironmentalFeature": {
         "description": "",
         "properties": {},
         "title": "EnvironmentalFeature",
         "type": "object"
      },
      "EnvironmentalProcess": {
         "description": "",
         "properties": {
            "has_input": {
               "description": "holds between a process and a continuant, where the continuant is an input into the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_output": {
               "description": "holds between a process and a continuant, where the continuant is an output of the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_participant": {
               "description": "holds between a process and a continuant, where the continuant is somehow involved in the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "precedes": {
               "description": "holds between two processes, where one completes before the other begins",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "regulates_process_to_process": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "EnvironmentalProcess",
         "type": "object"
      },
      "EvidenceType": {
         "description": "Class of evidence that supports an association",
         "properties": {},
         "title": "EvidenceType",
         "type": "object"
      },
      "Exon": {
         "description": "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing",
         "properties": {},
         "title": "Exon",
         "type": "object"
      },
      "ExonToTranscriptRelationship": {
         "description": "A transcript is formed from multiple exons",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "ExonToTranscriptRelationship",
         "type": "object"
      },
      "FrequencyQualifierMixin": {
         "description": "Qualifier for freqency type associations",
         "properties": {
            "frequency_qualifier": {
               "description": "a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject",
               "type": "string"
            }
         },
         "title": "FrequencyQualifierMixin",
         "type": "object"
      },
      "FrequencyQuantifier": {
         "description": "",
         "properties": {
            "has_count": {
               "description": "number of things with a particular property",
               "type": "string"
            },
            "has_percentage": {
               "description": "equivalent to has quotient multiplied by 100",
               "type": "string"
            },
            "has_quotient": {
               "type": "string"
            },
            "has_total": {
               "description": "total number of things in a particular reference set",
               "type": "string"
            }
         },
         "title": "FrequencyQuantifier",
         "type": "object"
      },
      "FrequencyValue": {
         "description": "describes the frequency of occurrence of an event or condition",
         "properties": {},
         "title": "FrequencyValue",
         "type": "object"
      },
      "FunctionalAssociation": {
         "description": "An association between a macromolecular machine (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "FunctionalAssociation",
         "type": "object"
      },
      "Gene": {
         "description": "",
         "properties": {
            "gene_associated_with_condition": {
               "description": "holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "genetically_interacts_with": {
               "description": "holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_gene_product": {
               "description": "holds between a gene and a transcribed and/or translated product generated from it",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "Gene",
         "type": "object"
      },
      "GeneAsAModelOfDiseaseAssociation": {
         "description": "",
         "properties": {
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneAsAModelOfDiseaseAssociation",
         "type": "object"
      },
      "GeneFamily": {
         "description": "any grouping of multiple genes or gene products related by common descent",
         "properties": {},
         "title": "GeneFamily",
         "type": "object"
      },
      "GeneHasVariantThatContributesToDiseaseAssociation": {
         "description": "",
         "properties": {
            "sequence_variant_qualifier": {
               "description": "a qualifier used in an association where the variant",
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneHasVariantThatContributesToDiseaseAssociation",
         "type": "object"
      },
      "GeneOntologyClass": {
         "description": "an ontology class that describes a functional aspect of a gene, gene prodoct or complex",
         "properties": {},
         "title": "GeneOntologyClass",
         "type": "object"
      },
      "GeneOrGeneProduct": {
         "description": "a union of genes or gene products. Frequently an identifier for one will be used as proxy for another",
         "properties": {
            "expressed_in": {
               "description": "holds between a gene or gene product and an anatomical entity in which it is expressed",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "in_cell_population_with": {
               "description": "holds between two genes or gene products that are expressed in the same cell type or population",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "in_complex_with": {
               "description": "holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "in_pathway_with": {
               "description": "holds between two genes or gene products that are part of in the same biological pathway",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "GeneOrGeneProduct",
         "type": "object"
      },
      "GeneProduct": {
         "description": "The functional molecular product of a single gene. Gene products are either proteins or functional RNA molecules",
         "properties": {},
         "title": "GeneProduct",
         "type": "object"
      },
      "GeneRegulatoryRelationship": {
         "description": "A regulatory relationship between two genes",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneRegulatoryRelationship",
         "type": "object"
      },
      "GeneToDiseaseAssociation": {
         "description": "",
         "properties": {
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneToDiseaseAssociation",
         "type": "object"
      },
      "GeneToExpressionSiteAssociation": {
         "description": "An association between a gene and an expression site, possibly qualified by stage/timing info.",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "quantifier_qualifier": {
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "stage_qualifier": {
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneToExpressionSiteAssociation",
         "type": "object"
      },
      "GeneToGeneHomologyAssociation": {
         "description": "A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)",
         "properties": {
            "relation": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneToGeneHomologyAssociation",
         "type": "object"
      },
      "GeneToGeneProductRelationship": {
         "description": "A gene is transcribed and potentially translated to a gene product",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneToGeneProductRelationship",
         "type": "object"
      },
      "GeneToGoTermAssociation": {
         "description": "",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneToGoTermAssociation",
         "type": "object"
      },
      "GeneToPhenotypicFeatureAssociation": {
         "description": "",
         "properties": {
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GeneToPhenotypicFeatureAssociation",
         "type": "object"
      },
      "Genome": {
         "description": "A genome is the sum of genetic material within a cell or virion.",
         "properties": {},
         "title": "Genome",
         "type": "object"
      },
      "GenomicEntity": {
         "description": "an entity that can either be directly located on a genome (gene, transcript, exon, regulatory region) or is encoded in a genome (protein)",
         "properties": {
            "has_biological_sequence": {
               "description": "connects a genomic feature to its sequence",
               "type": "string"
            }
         },
         "title": "GenomicEntity",
         "type": "object"
      },
      "GenomicSequenceLocalization": {
         "description": "A relationship between a sequence feature and an entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig",
         "properties": {
            "end_interbase_coordinate": {
               "type": "string"
            },
            "genome_build": {
               "description": "TODO",
               "type": "string"
            },
            "object": {
               "required": true,
               "type": "string"
            },
            "phase": {
               "description": "TODO",
               "type": "string"
            },
            "start_interbase_coordinate": {
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GenomicSequenceLocalization",
         "type": "object"
      },
      "Genotype": {
         "description": "An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some extablished background",
         "properties": {
            "has_zygosity": {
               "type": "string"
            }
         },
         "title": "Genotype",
         "type": "object"
      },
      "GenotypeToGeneAssociation": {
         "description": "Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GenotypeToGeneAssociation",
         "type": "object"
      },
      "GenotypeToGenotypePartAssociation": {
         "description": "Any association between one genotype and a genotypic entity that is a sub-component of it",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GenotypeToGenotypePartAssociation",
         "type": "object"
      },
      "GenotypeToPhenotypicFeatureAssociation": {
         "description": "Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment",
         "properties": {
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GenotypeToPhenotypicFeatureAssociation",
         "type": "object"
      },
      "GenotypeToVariantAssociation": {
         "description": "Any association between a genotype and a sequence variant.",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "GenotypeToVariantAssociation",
         "type": "object"
      },
      "GenotypicSex": {
         "description": "An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes.",
         "properties": {},
         "title": "GenotypicSex",
         "type": "object"
      },
      "GeographicLocation": {
         "description": "a location that can be described in lat/long coordinates",
         "properties": {
            "latitude": {
               "description": "latitude",
               "type": "string"
            },
            "longitude": {
               "description": "longitude",
               "type": "string"
            }
         },
         "title": "GeographicLocation",
         "type": "object"
      },
      "GeographicLocationAtTime": {
         "description": "a location that can be described in lat/long coordinates, for a particular time",
         "properties": {
            "timepoint": {
               "description": "a point in time",
               "type": "string"
            }
         },
         "title": "GeographicLocationAtTime",
         "type": "object"
      },
      "GrossAnatomicalStructure": {
         "description": "",
         "properties": {},
         "title": "GrossAnatomicalStructure",
         "type": "object"
      },
      "Haplotype": {
         "description": "A set of zero or more Alleles on a single instance of a Sequence[VMC]",
         "properties": {},
         "title": "Haplotype",
         "type": "object"
      },
      "IndividualOrganism": {
         "description": "",
         "properties": {
            "in_taxon": {
               "description": "connects a thing to a class representing a taxon",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "IndividualOrganism",
         "type": "object"
      },
      "LifeStage": {
         "description": "A stage of development or growth of an organism, including post-natal adult stages",
         "properties": {
            "in_taxon": {
               "description": "connects a thing to a class representing a taxon",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "LifeStage",
         "type": "object"
      },
      "MacromolecularComplex": {
         "description": "",
         "properties": {},
         "title": "MacromolecularComplex",
         "type": "object"
      },
      "MacromolecularMachine": {
         "description": "A union of gene, gene product, and macromolecular complex. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this.",
         "properties": {
            "name": {
               "required": true,
               "type": "string"
            }
         },
         "title": "MacromolecularMachine",
         "type": "object"
      },
      "MacromolecularMachineToBiologicalProcessAssociation": {
         "description": "A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "MacromolecularMachineToBiologicalProcessAssociation",
         "type": "object"
      },
      "MacromolecularMachineToCellularComponentAssociation": {
         "description": "A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "MacromolecularMachineToCellularComponentAssociation",
         "type": "object"
      },
      "MacromolecularMachineToMolecularActivityAssociation": {
         "description": "A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            }
         },
         "title": "MacromolecularMachineToMolecularActivityAssociation",
         "type": "object"
      },
      "MaterialSample": {
         "description": "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]",
         "properties": {
            "has_attribute": {
               "description": "connects any named thing to an attribute",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "MaterialSample",
         "type": "object"
      },
      "MaterialSampleDerivationAssociation": {
         "description": "An association between a material sample and the material entity it is derived from",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "MaterialSampleDerivationAssociation",
         "type": "object"
      },
      "MaterialSampleToDiseaseOrPhenotypicFeatureAssociation": {
         "description": "An association between a material sample and a disease or phenotype",
         "properties": {},
         "title": "MaterialSampleToDiseaseOrPhenotypicFeatureAssociation",
         "type": "object"
      },
      "Metabolite": {
         "description": "Any intermediate or product resulting from metabolism. Includes primary and secondary metabolites.",
         "properties": {},
         "title": "Metabolite",
         "type": "object"
      },
      "MicroRNA": {
         "description": "",
         "properties": {},
         "title": "MicroRNA",
         "type": "object"
      },
      "MolecularActivity": {
         "description": "An execution of a molecular function carried out by a gene product or macromolecular complex.",
         "properties": {
            "enabled_by": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_input": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_output": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "MolecularActivity",
         "type": "object"
      },
      "MolecularEntity": {
         "description": "A gene, gene product, small molecule or macromolecule (including protein complex)",
         "properties": {
            "affects_abundance_of": {
               "description": "holds between two molecular entities where the action or effect of one changes the amount of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_activity_of": {
               "description": "holds between two molecular entities where the action or effect of one changes the activity of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_degradation_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the rate of degradation of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_expression_of": {
               "description": "holds between two molecular entities where the action or effect of one changes the level of expression of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_folding_of": {
               "description": "holds between two molecular entities where the action or effect of one changes the rate or quality of folding of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_localization_of": {
               "description": "holds between two molecular entities where the action or effect of one changes the localization of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_metabolic_processing_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the metabolic processing of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_molecular_modification_of": {
               "description": "holds between two molecular entities where the action or effect of one leads changes in the molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_mutation_rate_of": {
               "description": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity impacts the rate of mutation of the genomic entity within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_response_to": {
               "description": "holds between two molecular entities where the action or effect of one impacts the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_secretion_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the rate of secretion of the other out of a cell, gland, or organ",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_splicing_of": {
               "description": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity impacts the splicing of the mRNA",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_stability_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the stability of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_synthesis_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the rate of chemical synthesis of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_transport_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the rate of transport of the other across some boundary in a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_uptake_of": {
               "description": "holds between two molecular entities where the action or effect of one impacts the rate of uptake of the other into of a cell, gland, or organ",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "biomarker_for": {
               "description": "holds between a measurable molecular entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_abundance_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the amount of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_activity_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the activity of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_degradation_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate of degradation of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_expression_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the level of expression of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_folding_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate or quality of folding of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_localization_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the proper localization of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_metabolic_processing_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate of metabolic processing of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_molecular_modification_of": {
               "description": "holds between two molecular entities where the action or effect of one leads to decreased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_mutation_rate_of": {
               "description": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity decreases the rate of mutation of the genomic entity within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_response_to": {
               "description": "holds between two molecular entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_secretion_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate of secretion of the other out of a cell, gland, or organ",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_splicing_of": {
               "description": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity decreases the proper splicing of the mRNA",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_stability_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the stability of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_synthesis_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate of chemical synthesis of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_transport_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate of transport of the other across some boundary in a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "decreases_uptake_of": {
               "description": "holds between two molecular entities where the action or effect of one decreases the rate of uptake of the other into of a cell, gland, or organ",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "in_taxon": {
               "description": "connects a thing to a class representing a taxon",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_abundance_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the amount of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_activity_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the activity of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_degradation_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate of degradation of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_expression_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the level of expression of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_folding_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate or quality of folding of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_localization_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the proper localization of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_metabolic_processing_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate of metabolic processing of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_molecular_modification_of": {
               "description": "holds between two molecular entities where the action or effect of one leads to increased molecular modification(s) of the other (e.g. via post-translational modifications of proteins such as the addition of phosphoryl group, or via redox reaction that adds or subtracts electrons)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_mutation_rate_of": {
               "description": "holds between a molecular entity and a genomic entity where the action or effect of the molecular entity increases the rate of mutation of the genomic entity within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_response_to": {
               "description": "holds between two molecular entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine, biological or pathological process) to the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_secretion_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate of secretion of the other out of a cell, gland, or organ",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_splicing_of": {
               "description": "holds between a molecular entity and an mRNA where the action or effect of the molecular entity increases the proper splicing of the mRNA",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_stability_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the stability of the other within a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_synthesis_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate of chemical synthesis of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_transport_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate of transport of the other across some boundary in a system of interest",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "increases_uptake_of": {
               "description": "holds between two molecular entities where the action or effect of one increases the rate of uptake of the other into of a cell, gland, or organ",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "molecularly_interacts_with": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "negatively_regulates_entity_to_entity": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "positively_regulates_entity_to_entity": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "regulates_entity_to_entity": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "MolecularEntity",
         "type": "object"
      },
      "NamedThing": {
         "description": "a databased entity or concept/class",
         "properties": {
            "actively_involved_in": {
               "description": "holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects": {
               "description": "describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "affects_risk_for": {
               "description": "holds between two entities where exposure to one entity alters the chance of developing the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "aggregate_statistic": {
               "type": "string"
            },
            "capable_of": {
               "description": "holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "category": {
               "description": "Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class. In a neo4j database this MAY correspond to the neo4j label tag",
               "items": {
                  "type": "string"
               },
               "required": true,
               "type": "array"
            },
            "causes": {
               "description": "holds between two entities where the occurrence, existence, or activity of one causes the occurrence or  generation of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "coexists_with": {
               "description": "holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "colocalizes_with": {
               "description": "holds between two entities that are observed to be located in the same place.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "contributes_to": {
               "description": "holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "creation_date": {
               "description": "date on which thing was created. This can be applied to nodes or edges",
               "type": "string"
            },
            "derives_from": {
               "description": "holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "derives_into": {
               "description": "holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "description": {
               "description": "a human-readable description of a thing",
               "type": "string"
            },
            "disrupts": {
               "description": "describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "end_interbase_coordinate": {
               "type": "string"
            },
            "filler": {
               "description": "The value in a property-value tuple",
               "type": "string"
            },
            "full_name": {
               "description": "a long-form human readable name for a thing",
               "type": "string"
            },
            "genome_build": {
               "description": "TODO",
               "type": "string"
            },
            "has_biological_sequence": {
               "description": "connects a genomic feature to its sequence",
               "type": "string"
            },
            "has_chemical_formula": {
               "description": "description of chemical compound based on element symbols",
               "type": "string"
            },
            "has_count": {
               "description": "number of things with a particular property",
               "type": "string"
            },
            "has_gene": {
               "description": "connects and entity to a single gene",
               "type": "string"
            },
            "has_molecular_consequence": {
               "description": "connects a sequence variant to a class describing the molecular consequence. E.g.  SO:0001583",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_part": {
               "description": "holds between wholes and their parts (material entities or processes)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_percentage": {
               "description": "equivalent to has quotient multiplied by 100",
               "type": "string"
            },
            "has_quotient": {
               "type": "string"
            },
            "has_total": {
               "description": "total number of things in a particular reference set",
               "type": "string"
            },
            "has_zygosity": {
               "type": "string"
            },
            "homologous_to": {
               "description": "holds between two biological entities that have common evolutionary origin",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "id": {
               "description": "A unique identifier for a thing. Must be either a CURIE shorthand for a URI or a complete URI",
               "required": true,
               "type": "string"
            },
            "interacts_with": {
               "description": "holds between any two entities that directly or indirectly interact with each other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "interbase_coordinate": {
               "description": "TODO",
               "type": "string"
            },
            "iri": {
               "description": "An IRI for the node. This is determined by the id using expansion rules.",
               "type": "string"
            },
            "latitude": {
               "description": "latitude",
               "type": "string"
            },
            "located_in": {
               "description": "holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "location_of": {
               "description": "holds between material entity or site and a material entity that is located within it (but not considered a part of it)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "longitude": {
               "description": "longitude",
               "type": "string"
            },
            "manifestation_of": {
               "description": "used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "model_of": {
               "description": "holds between an entity and some other entity it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "name": {
               "description": "A human-readable name for a thing",
               "required": true,
               "type": "string"
            },
            "negatively_regulates": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "node_property": {
               "description": "A grouping for any property that holds between a node and a value",
               "type": "string"
            },
            "occurs_in": {
               "description": "holds between a process and a material entity or site within which the process occurs",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "orthologous_to": {
               "description": "a homology relationship between entities (typically genes) that diverged after a speciation event.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "overlaps": {
               "description": "holds between entties that overlap in their extents (materials or processes)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "paralogous_to": {
               "description": "a homology relationship that holds between entities (typically genes) that diverged after a duplication event.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "part_of": {
               "description": "holds between parts and wholes (material entities or processes)",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "participates_in": {
               "description": "holds between a continuant and a process, where the continuant is somehow involved in the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "phase": {
               "description": "TODO",
               "type": "string"
            },
            "physically_interacts_with": {
               "description": "holds between two entities that make physical contact as part of some interaction",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "positively_regulates": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "predisposes": {
               "description": "holds between two entities where exposure to one entity increases the chance of developing the other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "prevents": {
               "description": "holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical substance, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "produces": {
               "description": "holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "regulates": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "related_to": {
               "description": "A relationship that is asserted between two named things",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "same_as": {
               "description": "holds between two entities that are considered equivalent to each other",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "start_interbase_coordinate": {
               "type": "string"
            },
            "synonym": {
               "description": "Alternate human-readable names for a thing",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "systematic_synonym": {
               "description": "more commonly used for gene symbols in yeast",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "timepoint": {
               "description": "a point in time",
               "type": "string"
            },
            "type": {
               "type": "string"
            },
            "update_date": {
               "description": "date on which thing was updated. This can be applied to nodes or edges",
               "type": "string"
            },
            "xenologous_to": {
               "description": "a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor.",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "NamedThing",
         "type": "object"
      },
      "NoncodingRNAProduct": {
         "description": "",
         "properties": {},
         "title": "NoncodingRNAProduct",
         "type": "object"
      },
      "Occurrent": {
         "description": "A processual entity",
         "properties": {
            "enabled_by": {
               "description": "holds between a process and a physical entity, where the physical entity executes the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_input": {
               "description": "holds between a process and a continuant, where the continuant is an input into the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_output": {
               "description": "holds between a process and a continuant, where the continuant is an output of the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "has_participant": {
               "description": "holds between a process and a continuant, where the continuant is somehow involved in the process",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "negatively_regulates_process_to_process": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "positively_regulates_process_to_process": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "precedes": {
               "description": "holds between two processes, where one completes before the other begins",
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "regulates_process_to_process": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "Occurrent",
         "type": "object"
      },
      "Onset": {
         "description": "The age group in which manifestations appear",
         "properties": {},
         "title": "Onset",
         "type": "object"
      },
      "OntologyClass": {
         "description": "a concept or class in an ontology, vocabulary or thesaurus",
         "properties": {
            "subclass_of": {
               "description": "holds between two classes where the domain class is a specialization of the range class",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "OntologyClass",
         "type": "object"
      },
      "OrganismTaxon": {
         "description": "",
         "properties": {},
         "title": "OrganismTaxon",
         "type": "object"
      },
      "PairwiseGeneToGeneInteraction": {
         "description": "An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)",
         "properties": {
            "relation": {
               "required": true,
               "type": "string"
            }
         },
         "title": "PairwiseGeneToGeneInteraction",
         "type": "object"
      },
      "PathognomonicityQuantifier": {
         "description": "A relationship quantifier between a variant or symptom and a disease, which is high when the presence of the feature implies the existence of the disease",
         "properties": {},
         "title": "PathognomonicityQuantifier",
         "type": "object"
      },
      "Pathway": {
         "description": "",
         "properties": {},
         "title": "Pathway",
         "type": "object"
      },
      "Phenomenon": {
         "description": "a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question",
         "properties": {},
         "title": "Phenomenon",
         "type": "object"
      },
      "PhenotypicFeature": {
         "description": "",
         "properties": {},
         "title": "PhenotypicFeature",
         "type": "object"
      },
      "PhenotypicSex": {
         "description": "An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present.",
         "properties": {},
         "title": "PhenotypicSex",
         "type": "object"
      },
      "PhysicalEntity": {
         "description": "An entity that has physical properties such as mass, volume, or charge",
         "properties": {},
         "title": "PhysicalEntity",
         "type": "object"
      },
      "PhysiologicalProcess": {
         "description": "",
         "properties": {},
         "title": "PhysiologicalProcess",
         "type": "object"
      },
      "PlanetaryEntity": {
         "description": "Any entity or process that exists at the level of the whole planet",
         "properties": {},
         "title": "PlanetaryEntity",
         "type": "object"
      },
      "PopulationOfIndividualOrganisms": {
         "description": "A collection of individuals from the same taxonomic class distinguished by one or more characteristics. Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes [Alliance for Genome Resources]",
         "properties": {
            "in_taxon": {
               "description": "connects a thing to a class representing a taxon",
               "items": {
                  "type": "string"
               },
               "type": "array"
            }
         },
         "title": "PopulationOfIndividualOrganisms",
         "type": "object"
      },
      "PopulationToPopulationAssociation": {
         "description": "An association between a two populations",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "PopulationToPopulationAssociation",
         "type": "object"
      },
      "Procedure": {
         "description": "A series of actions conducted in a certain order or manner",
         "properties": {},
         "title": "Procedure",
         "type": "object"
      },
      "Protein": {
         "description": "A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA",
         "properties": {},
         "title": "Protein",
         "type": "object"
      },
      "ProteinIsoform": {
         "description": "Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/",
         "properties": {},
         "title": "ProteinIsoform",
         "type": "object"
      },
      "Provider": {
         "description": "person, group, organization or project that provides a piece of information",
         "properties": {},
         "title": "Provider",
         "type": "object"
      },
      "Publication": {
         "description": "Any published piece of information. Can refer to a whole publication, or to a part of it (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web as well as journals.",
         "properties": {},
         "title": "Publication",
         "type": "object"
      },
      "QuantityValue": {
         "description": "A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value",
         "properties": {
            "has_numeric_value": {
               "description": "connects a quantity value to a number",
               "type": "string"
            },
            "has_unit": {
               "description": "connects a quantity value to a unit",
               "type": "string"
            }
         },
         "title": "QuantityValue",
         "type": "object"
      },
      "RNAProduct": {
         "description": "",
         "properties": {},
         "title": "RNAProduct",
         "type": "object"
      },
      "RNAProductIsoform": {
         "description": "Represents a protein that is a specific isoform of the canonical or reference RNA",
         "properties": {},
         "title": "RNAProductIsoform",
         "type": "object"
      },
      "RelationshipType": {
         "description": "An OWL property used as an edge label",
         "properties": {},
         "title": "RelationshipType",
         "type": "object"
      },
      "SensitivityQuantifier": {
         "description": "",
         "properties": {},
         "title": "SensitivityQuantifier",
         "type": "object"
      },
      "SequenceFeatureRelationship": {
         "description": "For example, a particular exon is part of a particular transcript or gene",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "SequenceFeatureRelationship",
         "type": "object"
      },
      "SequenceVariant": {
         "description": "An allele that varies in its sequence from what is considered the reference allele at that locus.",
         "properties": {
            "has_biological_sequence": {
               "type": "string"
            },
            "has_gene": {
               "items": {
                  "type": "string"
               },
               "type": "array"
            },
            "id": {
               "required": true,
               "type": "string"
            }
         },
         "title": "SequenceVariant",
         "type": "object"
      },
      "SeverityValue": {
         "description": "describes the severity of a phenotypic feature or disease",
         "properties": {},
         "title": "SeverityValue",
         "type": "object"
      },
      "SourceFile": {
         "description": "",
         "properties": {
            "retrievedOn": {
               "type": "string"
            },
            "source_version": {
               "type": "string"
            }
         },
         "title": "SourceFile",
         "type": "object"
      },
      "SpecificityQuantifier": {
         "description": "",
         "properties": {},
         "title": "SpecificityQuantifier",
         "type": "object"
      },
      "Transcript": {
         "description": "An RNA synthesized on a DNA or RNA template by an RNA polymerase",
         "properties": {},
         "title": "Transcript",
         "type": "object"
      },
      "TranscriptToGeneRelationship": {
         "description": "A gene is a collection of transcripts",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "TranscriptToGeneRelationship",
         "type": "object"
      },
      "Treatment": {
         "description": "A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures'",
         "properties": {
            "has_exposure_parts": {
               "items": {
                  "type": "string"
               },
               "required": true,
               "type": "array"
            },
            "treats": {
               "description": "holds between a therapeutic procedure or chemical substance and a disease or phenotypic feature that it is used to treat",
               "items": {
                  "type": "string"
               },
               "required": true,
               "type": "array"
            }
         },
         "title": "Treatment",
         "type": "object"
      },
      "VariantToDiseaseAssociation": {
         "description": "",
         "properties": {
            "object": {
               "required": true,
               "type": "string"
            },
            "relation": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "VariantToDiseaseAssociation",
         "type": "object"
      },
      "VariantToPhenotypicFeatureAssociation": {
         "description": "",
         "properties": {
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "VariantToPhenotypicFeatureAssociation",
         "type": "object"
      },
      "VariantToPopulationAssociation": {
         "description": "An association between a variant and a population, where the variant has particular frequency in the population",
         "properties": {
            "has_count": {
               "type": "string"
            },
            "has_percentage": {
               "description": "equivalent to has quotient multiplied by 100",
               "type": "string"
            },
            "has_quotient": {
               "type": "string"
            },
            "has_total": {
               "type": "string"
            },
            "object": {
               "required": true,
               "type": "string"
            },
            "subject": {
               "required": true,
               "type": "string"
            }
         },
         "title": "VariantToPopulationAssociation",
         "type": "object"
      },
      "Zygosity": {
         "description": "",
         "properties": {},
         "title": "Zygosity",
         "type": "object"
      }
   },
   "title": "biolink_model",
   "type": "object"
}